Modulation of L-α-lysophosphatidylinositol /gpr55 Map Kinase Signalling by Cannabinoids
نویسندگان
چکیده
School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK; Division of Medical Sciences, Ninewells Hospital and Medical School, University of Dundee, DD1 9SY, UK; Institute of Biochemistry and Molecular Medicine, University of Bern, Bühlstrasse 28, CH-3012, Bern, Switzerland; Departments of Behavioral Sciences & Molecular Biology, Ariel University Center of Samaria, Israel, 40700 Running title: Pharmacology of GPR55 ligands Address correspondence to: Sharon Anavi-Goffer, Departments of Behavioral Sciences & Molecular Biology, Ariel University Center of Samaria, Israel, E-mail: [email protected]
منابع مشابه
Functional characterization of the novel cannabinoid receptor GPR55 and its modulation by CB1 and CB2 receptors
We have recently shown that the G protein-coupled receptor 55 (GPR55) mediates intracellular effects of cannabinoids and other, non-cannabionid, ligands in addition to the classical cannabinoid 1 (CB1R) and 2 (CB2R) receptors. Here we show that the presence of either CB1R or CB2R alters the signaling pathways of GPR55. HEK-293 cells stably expressing either the GPR55 receptor alone or in combin...
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GPR55 was recently identified as a putative receptor for certain cannabinoids, and lysophosphatidylinositol (LPI). Recently, the role of cannabinoids as GPR55 agonists has been disputed by a number of reports, in part, because studies investigating GPR55 often utilized overexpression systems, such as the GPR55-overexpressing HEK293 cells, which make it difficult to deduce the physiological role...
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Background The G protein-coupled receptor 55 (GPR55) has recently been suggested to be responsible for those cannabinoid responses that could not be attributed to either the cannabinoid 1 (CB1) or cannabinoid 2 (CB2) receptor. Several potent GPR55 agonists were identified such as lysophosphatidylinositol (LPI) and several synthetic cannabinoids: One of these is rimonabant (SR141716A), an antago...
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GPR55 is a putative cannabinoid receptor, and l-α-lysophosphatidylinositol (LPI) is its only known endogenous ligand. We investigated 1) whether GPR55 is expressed in fat and liver; 2) the correlation of both GPR55 and LPI with several metabolic parameters; and 3) the actions of LPI on human adipocytes. We analyzed CB1, CB2, and GPR55 gene expression and circulating LPI levels in two independen...
متن کاملGPR55-dependent and -independent ion signalling in response to lysophosphatidylinositol in endothelial cells
BACKGROUND AND PURPOSE The glycerol-based lysophospholipid lysophosphatidylinositol (LPI) is an endogenous agonist of the G-protein-coupled receptor 55 (GPR55) exhibiting cannabinoid receptor-like properties in endothelial cells. To estimate the contribution of GPR55 to the physiological effects of LPI, the GPR55-dependent and -independent electrical responses in this cell type were investigate...
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